Attachment Style and Resiliency in Patients with Obsessive-Compulsive Personality Disorder / 가정의학회지

BACKGROUND: The goal of the present study was to determine the relationships between attachment styles and resiliency in obsessive-compulsive personality disorder. METHODS: A random sample of 260 subjects was obtained from the population of undergraduate students of the Nour Branch of Islamic Azad University, which is located in Mazandaran, and these subjects were enrolled in this descriptive and correlational study. The collected data included the subjects' responses to an adult attachment style questionnaire, resilience scale, and obsessive-compulsive personality disorder questionnaire. The data were analyzed with Pearson correlation coefficient indices and multiple regressions. RESULTS: The results of the data analysis showed a positive correlation (relationship) between ambivalent/avoidant attachment styles and obsessive-compulsive personality disorder and a negative correlation between resilience and obsessive-compulsive personality disorder. Furthermore, these results demonstrated that attachment style and resiliency can predict obsessive-compulsive personality disorder. In addition, no significant relationships were found between the demographic variables (convertibles) and obsessive-compulsive personality disorder. CONCLUSION: These results suggested that attachment style and resiliency contribute to the development of obsessive-compulsive personality disorder.

Hoarding disorder: a new diagnostic category in ICD-11?

Despite the long-held view that hoarding is a symptom of both obsessive-compulsive disorder and obsessive-compulsive personality disorder, increased evidence has emerged during the last 20 years suggesting that hoarding represents a distinct form of psychopathology. This study reflects the discussions on the nosological status of hoarding carried out by the WHO ICD-11 Working Group on the Classification of Obsessive-Compulsive and Related Disorders. The distinctiveness of hoarding is based on its having core symptoms that differ from those of other disorders, as well as distinctive neurobiological correlates and treatment responses. Furthermore, data showing the clinical utility, global applicability, and appropriateness of the concept of hoarding disorder outside specialty mental health settings suggest that this condition should be included in ICD-11. Finally, given the focus of ICD-11 on primary care and public health, the Working Group suggests that poor insight and severe domestic squalor may be considered as specifiers for hoarding disorder in ICD-11.

Escitalopram combined with aripiprazole in the treatment of 46 patients with obsessive compulsive disorder / 中国基层医药

ObjectiveTo observe and explore the clinical efficacy and safety of escitalopram combined with aripiprazole in the treatment of obsessive-compulsive disorder.Methods97 patients with obsessive-compulsive disorder were randomly divided into two groups,control group of 51 patients were given oral administration of escitalopram treatment,46 patients in the experimental group received escitalopram and oral aripiprazole treatment.At the end of treatment,the clinical efficacy and adverse events were evaluated.ResultsIn control group and experimental group patients overall effective rate was 68.6％,89.1％ ;The experimental group the total effective rate was higher than the control group,the difference between two groups was statistically significant( x2 =12.32,P ＜0.05 ),The control group and experimental group after treatment Y-BOCS scores were (23.68 ± 2.74 ) points,( 21.82 ± 2.88 ) points ; The experimental group after treatment Y-BOCS score was significantly better than the control group,between the two groups the difference was statistically significant ( t =2.64,P ＜ 0.05 ) ; While after treatment the TESS score and incidence of adverse reactions between the two groups were not statistically different ( t =0.61 ; x2 =0.03,all P ＞ 0.05 ).ConclusionEscitalopram combined with aripiprazole in the treatment of obsessive compulsive disorder obtain excellent effect,had few adverse reactions,and was worthy of clinical application.

An optimized voxel-based morphometry study of gray matter abnormalities in patients with obsessive-compulsive disorder / 中华放射学杂志

Objective To explore changes of gray matter volume in patients with obsessivecompulsive disorder (OCD) in Chinese Han population using optimized voxel-based morphometry (VBM) ,and investigate its relationship with clinical symptoms. Methods Twenty patients with OCD and 20 age,sex and handedness matched healthy controls were scanned using 3D-T1 images on a 3.0 T MR system. The high resolution T1WI was preprocessed according to the optimized VBM protocol in Statistical Parametric Mapping (SPM5). Two-sample t test was performed to characterize the differences of the gray matter volume (GMV) between the OCD patients and healthy controls, and the correlations between the GMV and symptom severity and cumulative illness duration were examined using Pearson correlation in SPSS 16. 0, respectively.Results Compared to controls, OCD patients demonstrated increased GMV in left thalamus, right thalamus and left cerebellum after false discovery rate (FDR) correction. No areas of significantly decreased GMV was observed in OCD patients in relative to healthy controls. The mean eigenvalue ranged from 0. 5782 to 0. 889 representing the left thalamus volume of OCD patients was 0. 6813 ± 0. 0718, and that ranged from 0. 5546 to 0. 9062 was 0. 6869 ± 0. 0808 tor right thalamus. The mean eigenvalues were positively correlated in bilateral thalamus (r = 0. 94, P ＜ 0. 01). Conclusion Using optimized VBM, the current research indicates that the pathophysiology of OCD is associated with GMV abnormalities not only in corticostriato-thalamo-cortical (CSTC) circuit, but also in the cerebellum.